Glucose-6-phosphate Dehydrogenase Deficiency (G6PDD )
By: Francis Appiah, Doctor of Naturopathic Medicine (N.D. Candidate), with expertise in Medical Journalism, Medical Laboratory Science, Integrative/Complementary Health, CAM and Healthcare Management Glucose-6-phosphate dehydrogenase deficiency (G6PD) is an inborn error of metabolism that predisposes to red blood cell breakdown. Most individuals with G6PD deficiency are asymptomatic thus those who are affected have no symptoms. Following a specific trigger, symptoms such as yellowish skin, Hemoglobinuria (red, dark or brown urine), shortness of breath, and feeling tired may develop. Complications can include anemia, acute kidney failure and newborn jaundice. Most people who develop symptom of G6PD are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization. Carriers of the G6PDD allele may be partially protected against malaria. It is an X-linked recessive disorder that results in defective glucose-6-phosphate dehydrog...